Loss of chromosome 10, retinoblastoma and deleted-in-colon-carcinoma (DCC) proteins in glioblastomas

but were increased around areas of necrosis and around blood vessels. No relationship between tumour cell proliferation and necrosis was detected. Conclusions: Tumour cell proliferation is concentrated around blood vessels in glioblastomas. Blood vessel proliferation, but not tumour cell proliferation, is related to areas of necrosis and the presence of macrophages in glioblastomas. Targeting of blood vessel proliferation and macrophages within glioblastoma may present a therapeutic strategy for treatment of these devastating tumours.